Health state utilities associated with hyperphagia: Data for use in cost‐utility models

Objective Rare genetic diseases of obesity typically present with hyperphagia, a pathologic desire to consume food. Cost-utility models assessing the value treatments for these rare will require health state utilities representing hyperphagia. This study estimated associated various hyperphagia severity levels. Methods Four vignettes were developed using published literature and clinician input represent levels Utilities states in time trade-off elicitation UK general population sample. Results In total, 215 participants completed interviews (39.5% male; mean age 39.1 years). Mean (SD) 0.98 (0.02) no 0.91 (0.10) mild 0.70 (0.30) moderate 0.22 (0.59) severe disutilities −0.08 mild, −0.28 moderate, −0.77 (0.58) Conclusions These data show increasing is decreased utility. are similar those other conditions severely impacting quality life (QoL). findings highlight that addressing substantial QoL impacts needed. here may be useful cost-utility obesity.